Monitoring of Vascular Endothelial Growth Factor in POEMS Syndrome
نویسندگان
چکیده
POEMS syndrome is a clinical unit with a very heterogenous clinical behavior. Its diagnostics as well as monitoring are not easy and depend on clinician ́s experience. We present three case reports of patients with POEMS syndrome with different clinical manifestation and course of the disease. Our presentation demonstrates the benefit of the use of biochemical parameter VEGF (vascular endothelial growth factor). Retrospective analysis revealed that VEGF behaved accordingly with the state of the disease, i.e. it increased in active phase and decreased with remission of the disease. We suggest the use of VEGF not only for the diagnostics but also as a potential marker of therapeutic response and for monitoring of the course of POEMS syndrome.
منابع مشابه
Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome refractory to complete serum vascular endothelial growth factor (VEGF) blockade: insights from sequential VEGF monitoring
Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome is a systemic condition related to plasma cell dyscrasia. Increased vascular permeability is responsible for some of the hallmarks of this disorder that may include renal microangiopathy. Several lines of evidence suggest that vascular endothelial growth factor (VEGF) is central to the pathogenesis o...
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